• EZ Cap™ Human PTEN mRNA (ψUTP): Transforming PI3K/Akt Pat...

  2025-09-29

  Explore how EZ Cap™ Human PTEN mRNA (ψUTP) enables next-generation inhibition of the PI3K/Akt pathway through advanced mRNA engineering. This article uniquely examines the molecular mechanisms, delivery innovations, and experimental best practices that distinguish this tool for cancer research.

• Ferrostatin-1 (Fer-1): Precision Inhibition of Ferroptosi...

  2025-09-28

  Unlock the scientific potential of Ferrostatin-1 (Fer-1), a selective ferroptosis inhibitor, in dissecting iron-dependent oxidative cell death. Explore unique mechanistic insights and emerging applications in cancer, neurodegeneration, and ischemic injury models.

• Paclitaxel (Taxol) in Translational Cancer Research: Beyo...

  2025-09-27

  Discover how Paclitaxel (Taxol) advances cancer research as a microtubule polymer stabilizer and anti-angiogenic agent. This article uniquely explores its translational applications, neurotoxicity modeling, and integration with emerging mRNA therapies.

• S63845: Redefining MCL1 Inhibition for Networked Apoptosi...

  2025-09-26

  Explore S63845, a potent MCL1 inhibitor, as a systems-level tool to unravel mitochondrial apoptotic pathway regulation and networked cell death in cancer models. This article uniquely examines S63845's role at the intersection of intrinsic-extrinsic apoptosis and emerging combinatorial strategies.

• (S)-Mephenytoin: Beyond Assay Substrate—Next-Gen Pharmaco...

  2025-09-25

  (S)-Mephenytoin, a premier CYP2C19 substrate, is revolutionizing advanced pharmacokinetic studies and personalized drug metabolism research. This article uniquely explores its role in dissecting CYP2C19 polymorphism, integrating human organoid models, and bridging translational gaps in oxidative drug metabolism.

• (S)-Mephenytoin: Unraveling CYP2C19 Substrate Dynamics in...

  2025-09-24

  (S)-Mephenytoin is a benchmark CYP2C19 substrate for elucidating cytochrome P450 metabolism in human intestinal organoids. This article uniquely explores in-depth mechanistic insights, kinetic parameters, and translational relevance for pharmacokinetic studies beyond conventional models.

• (S)-Mephenytoin as a Precision Tool for CYP2C19 Polymorph...

  2025-09-23

  (S)-Mephenytoin serves as a gold-standard CYP2C19 substrate, enabling rigorous investigation of cytochrome P450 metabolism and genetic polymorphisms in drug metabolism. This article explores its unique applications in next-generation in vitro models and pharmacogenetic studies.

• (S)-Mephenytoin as a Quantitative Probe in Intestinal Org...

  2025-09-22

  This article explores the application of (S)-Mephenytoin as a robust CYP2C19 substrate for quantitative assessment of drug metabolism in advanced human intestinal organoid models. Emphasis is placed on its kinetic properties, relevance in pharmacokinetic studies, and the evaluation of CYP2C19 genetic polymorphisms using hiPSC-derived systems.

• (S)-Mephenytoin in Human Intestinal Organoid CYP2C19 Assays

  2025-09-19

  (S)-Mephenytoin, a well-established mephenytoin 4-hydroxylase substrate, is invaluable for dissecting CYP2C19-mediated oxidative drug metabolism in advanced in vitro models. This article explores its application in human pluripotent stem cell-derived intestinal organoid systems for pharmacokinetic studies.

• (S)-Mephenytoin as a Probe for CYP2C19 in Advanced In Vit...

  2025-09-18

  Explore the role of (S)-Mephenytoin as a CYP2C19 substrate in cutting-edge in vitro systems, including hiPSC-derived intestinal organoids, and its applications in pharmacokinetic and cytochrome P450 metabolism research.

• The lactam emerged as lead candidate due to its

  2025-03-03

  

  The lactam (6) emerged as lead candidate due to its high selectivity, outstanding potency (against ALK or in clinically known ALK mutants), low in vitro clearance, and low efflux potential. The lactam (6) was selected for further profiling against the resistant ALK mutants. Preclinical rat pharmacok

• In the current study adiponectin receptors expressions were

  2025-03-03

  

  In the current study, adiponectin receptors expressions were detected in both cell lines. AdipoR2 showed equal expression levels, whereas AdipoR1 possessed different expression levels in both cell lines. There was a significant increase in the AdipoR1 mRNA levels in cell lines according to AdipoR2 m

• br Conclusions The present data suggest that homeostatic bal

  2025-03-03

  

  Conclusions The present data suggest that homeostatic balance of the cortical/hippocampal adenosinergic tone is necessary for normal working memory function and any deviation appears to impair performance – either as a consequence of A2AR under-activation when adenosine levels are reduced or due

• br Experimental Procedures br Acknowledgments br

  2025-03-03

  

  Experimental Procedures Acknowledgments Introduction Synapses are fundamental units for efficient communication between neurons and their target cells. Despite significant progress in understanding the structure of matured synapses, less is known about the mechanisms by which neurotransmitt

• Cancer immunotherapy Finasteride has been shown to be a mech

  2025-03-03

  

  Finasteride has been shown to be a mechanism-based inhibitor of 5AR-2 [9]. Finasteride acts as an alternate substrate for 5AR-2 and is initially bound in an extremely stable enzyme-bound NADP-dihydrofinasteride adduct which is ultimately processed to dihydrofinasteride. The NADP-dihydrofinasteride a

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