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br Acknowledgements br Introduction Serum triglyceride conce
2019-08-26
Acknowledgements Introduction Serum triglyceride concentrations increase following ingestion of a fat containing meal resulting in postprandial hyperlipidemia. Peak serum triglyceride levels are observed within 2 to 4h of fat consumption and then gradually return to baseline levels within appr
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br Materials and methods br Results br
2019-08-26
Materials and methods Results Discussion Recently, circRNAs have been found to play important diagnostic or prognostic roles in different tumors. For example, aberrant expression levels of different circRNAs are found in ovarian cancer, lung cancer, renal cancer, gastric cancer and particip
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Collectively the results presented here provide
2019-08-26
Collectively, the results presented here provide new insights into ligand binding, clustering, spatial distribution, and phosphorylation of DDR1b and DDR2 in response to soluble collagen I. As depicted in the cartoon of Scheme 1, we postulate a model in which the spatial distribution and assembly of
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Two in vitro reports using lung fibroblasts have shown
2019-08-26
Two in vitro reports using lung fibroblasts have shown that cell transmigration, using transwell migration experiments, through collagen I-coated inserts is mediated by DDR2 and the DDR2-associated signaling kinases JAK2 and ERK1/2, but not DDR1 [63] and that DDR2 regulates the adhesion of fibroblas
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More recently evidence suggests that dysregulation of CRF si
2019-08-26
More recently, evidence suggests that dysregulation of CRF signaling may also be implicated in panic disorder. For instance, polymorphisms in the CRF1, but not CRF2, gene have been associated with susceptibility to panic disorder in German and Japanese population samples (Ishitobi et al., 2012, Keck
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In general up to date no study
2019-08-26
In general, up to date, no study has considered thermodynamic modeling to estimate the Fmoc-Hyp-OH kinase of SO2 by different DESs. Since experimental measurements are time consuming and expensive, general and accurate theoretical models are vital to estimate SO2 solubilities in different DESs over
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BVT 2733 clinical br Discussion The present results
2019-08-26
Discussion The present results demonstrate that high dose estrogen–progestogen OC treatment produced impaired glucose tolerance and glucose tolerance was preserved during low dose estrogen–progestogen, high or low dose progestogen-only OC use. The study also shows that impaired glucose tolerance
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Cell lines which possess microglial or neuronal properties a
2019-08-24
Cell lines which possess microglial or neuronal properties are uncomplicated and convenient in vitro models for studying N,N-Dimethylsphingosine formula injury at the cellular and molecular levels. Microglial BV-2 cells are derived from the immortalized mouse microglia and exhibit many of the morpho
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Unexpectedly CRF receptor agonist and antagonist evoked
2019-08-24
Unexpectedly, CRF2 receptor agonist and antagonist evoked similar effects in the fall in tail skin temperature caused by restraint. However, Ucn3 reduced basal values of tail skin temperature, thus indicating that some degree of basal vasoconstriction caused by BNST treatment with Ucn3 may have cont
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Based on both the observational and theoretical data generat
2019-08-24
Based on both the observational and theoretical data generated in this study, it appears that the mechanism(s) underlying lower IFM CPT1 activity is complex. Modeling enzyme activity versus alterations in catalytic efficiency (Fig. 3A) suggests that the observed age-associated changes in Km and Vmax
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br Results Table shows demographics and clinical features
2019-08-24
Results Table 1 shows demographics and clinical features of subjects with obesity and controls. Before surgery five obese were diabetic, only one on glucose-lowering therapy; three obese were dyslipidemic and assumed lipid lowering medications. Lathosterol levels were significantly higher in pati
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br Methods br Results IAA abrogated the protective
2019-08-24
Methods Results IAA-94 abrogated the protective effects of IPC as it increased myocardial infarction (MI) due to IR injury in vitro (Diaz et al., 1999), and also prevented cyclosporine A mediated cardioprotection (Diaz et al., 2013). Moreover, IAA-94-sensitive currents were observed in cardiac
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Propranolol initially discovered in is
2019-08-24
Propranolol, initially discovered in 1964, is first and most widely studied as a non-selective beta-blocker. Propranolol through β-adrenergic receptor blockade has reduced heart rate and blood pressure and have anti-arrhythmogenic and anti-ischemic effects, and been proposed as an effective strategy
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br Chk and Chk mediated
2019-08-24
Chk 1 and Chk 2 mediated signaling act as a barrier to tumorigenesis It was hypothesized recently that early events during tumorigenesis, such as the overexpression of oncogenes, lead to a DNA-damage response which, in turn halts tumor progression [44], [45], [46]. The DNA-damage response is prop
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br Discussion We are reporting a cryptic insertion
2019-08-24
Discussion We are reporting a cryptic insertion of chromosome 22 material (EWS) to the long arm of chromosome 11 (11q24, FLI-1) recognizable by FISH in 3280 to exhibiting trisomy 8 as the sole cytogenetic anomaly. In ES and PNET tumors, trisomy 8 is the most common secondary abnormality [6]. Add
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