Multi electrode array approaches have been

2018-10-20

Multi-electrode array approaches have been proposed as a tool for detecting functional changes in electrically excitable cells, including neurons, exposed to drugs or toxins and allow use in high throughput studies (McConnell et al., 2012). Although there are a number of electrophysiological measure

We generated immortalized BMSC clones to perform detailed an

2018-10-20

We generated immortalized BMSC clones to perform detailed analysis of functional diversity in BMSC subtypes to levels not previously described. Similar immortalization techniques (e.g., hTERT combined with human papillomavirus E6/E7) have been used for the clonal analysis of BMSCs, which found OAC,

br Introduction Chronic kidney diseases CKDs

2018-10-20

Introduction Chronic kidney diseases (CKDs) affects ∼10% of the population and represent a major global health burden (Eckardt et al., 2013). Worldwide, the number of patients with end-stage renal disease (ESRD) receiving renal replacement therapy is estimated at more than 1.4 million, with an an

In previous tumor studies we have used

2018-10-20

In previous tumor studies, we have used a p53-null syngeneic mouse model to mimic p53 loss of function in human breast cancer. This model was developed by transplanting p53-null mammary epithelium into the cleared mammary fat pads of wild-type, syngeneic Balb/c-recipient mice, resulting in spontaneo

The present study indicated that induction of

2018-10-20

The present study indicated that induction of glutamatergic markers by nucleotides involved the P2Y4-Gq signaling axis. Expression of the P2Y4 nucleotide receptor was transiently augmented in the course of neuronal differentiation of ESCs, which is coincident with the window of nucleotide-induced vG

Obviously T changes are not

2018-10-20

Obviously, T2 changes are not specific for certain alterations in tazarotene current, as modulators with different modes of action (ATX-II, Bay K-8644, E-4031) all result in similar changes. Moreover, relaxation time was also prolonged by EMD-57033, a relatively pure calcium sensitizer that prolong

Here we describe the generation of the first L MYC

2018-10-20

Here we describe the generation of the first L-MYC-immortalized human NSC line derived from human fetal brain, for brevity referred to as LM-NSC008. We find that the LM-NSC008 line is chromosomally normal, and overexpresses several stem cell-associated genes. LM-NSC008 cells proliferate faster than

Hello world!

2018-07-29