• br Materials and methods br

  2018-10-22

  

  Materials and methods Results Discussion Acknowledgments This work was supported by a stem cell fund from Pennsylvania State University Eberly College of Science and grants from National Institute of Health (NIMH083911 and NIMH092740) to GC. FHG was supported by Transformative R01MH09574

• To further determine the generality

  2018-10-22

  

  To further determine the generality of our finding that iPSCs harbor unique transversion-predominant point mutation profiles (Figure S2D, left), we analyzed previously reported point mutation profiles in 27 different iPSC lines that had been established by various methods, including retrovirus, plas

• In addition our challenge was

  2018-10-22

  

  In addition, our challenge was to identify and characterize the hierarchical interactions between PTEN and BMAL1. Evidence of this possible interplay of BMAL1 and PTEN deficiency came from the observation that Bmal1 knockout mice have reduced the burden of squamous cell carcinoma and reduced CD34+α6

• The use of a novel Pax

  2018-10-22

  

  The use of a novel Pax9Venus reporter PSC line allowed the purification of PSC-derived Pax9+ AFE for molecular analysis and enabled the comparison to embryonic Pax9+ AFE. The expression of several pharyngeal endoderm transcription factors in PSC-derived Pax9+ AFE suggests that these paricalcitol ma

• br Mesenchymal stem cells The concept of cooperation between

  2018-10-20

  

  Mesenchymal stem cells The concept of cooperation between stem natural aromatase inhibitors and cardiomyocytes, functioning as supporting cells within the myocardial niches, has been documented carefully. The interaction between exogenously delivered bone marrow MSCs and endogenous c-kit-positiv

• calcium atpase br Introduction During early embryogenesis ec

  2018-10-20

  

  Introduction During early embryogenesis, ectoderm differentiates into surface ectoderm, neural crest, and neural tube. From the surface ectoderm, oral ectoderm and skin develop [1]. In turn, the oral ectoderm differentiates into the adenohypophysis [2,3], dental epithelia [1], salivary glands [1]

• continine br Resource table br Resource Details br Materials

  2018-10-20

  

  Resource table Resource Details Materials and methods Verification and authentication Resource table Resource Details Materials and methods Pluripotency assessment Sterility testing Verification and authentication Resource table Resource details Human skin fibrobl

• In the current study we used only gene expression

  2018-10-20

  

  In the current study, we used only gene expression data for the analysis; however, phosphoproteomics data could also be used to assign weights to the signaling interactome for the inference of niche determinants. An important limitation of the method is that it considers only DERs as the sources of

• The host immune response has

  2018-10-20

  

  The host immune response has been identified as a critical regulator of tumor development and progression (Dunn et al., 2004; Fridman et al., 2013; Hadrup et al., 2013). Several types of immune muscarinic receptor antagonists participate in immunosurveillance by direct killing or production of cyto

• topoisomerase inhibitors br Materials and methods br Author

  2018-10-20

  

  Materials and methods Author disclosure statement Acknowledgments This study was supported by fund from National Medical Research Council (NMRC) of China to SZ (fund number: 30400447) and HW (fund number: 30500548). Resource table. Resource details To engineer a biallelic mutation in t

• br Experimental Procedures A detailed version

  2018-10-20

  

  Experimental Procedures A detailed version of our Experimental Procedures can be found in the Supplemental Experimental Procedures. All animal experiments were approved by the Danish Council for Supervision with Experimental Animals (#2011/561-1966). AR was performed at P1 as previously described

• Introduction Reprogramming somatic cells to induced pluripot

  2018-10-20

  

  Introduction Reprogramming somatic cholinesterase inhibitor to induced pluripotent stem cells (iPSCs) holds great promise for disease modeling and therapeutic applications. Among the challenges that remain is the extended time frame and variable efficiency of transcription factor-based reprogrammi

• Mesenchymal stem cells MSCs from adult

  2018-10-20

  

  Mesenchymal stem RG2833 (MSCs) from adult tissues, with their ability to differentiate into several cell types, chondrocytes included, have been investigated as an alternative cell source (Dennis et al., 1999; Pittenger et al., 1999; Prockop, 1997). Unfortunately, despite their easy isolation and i

• Meanwhile in vitro studies of neural

  2018-10-20

  

  Meanwhile, in vitro studies of neural induction from hPSCs have suggested that radial arrangements of columnar neuroepithelial cells, termed neural rosettes, can differentiate toward peripheral nervous system (PNS) lineages (Chambers et al., 2009; Kim et al., 2010) and reported evidence of neural cr

• Based on these principles we

  2018-10-20

  

  Based on these principles, we speculated that the use of rBC2LCN as a cargo of cytotoxic agent would provide an efficient strategy to eliminate hPSCs. Here we generated a recombinant lectin-toxin fusion protein by fusing rBC2LCN with 23 kDa of a catalytic domain of Pseudomonas aeruginosa exotoxin A

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