• Atherosclerosis is a chronic lipid metabolism

  2025-02-24

  

  Atherosclerosis is a chronic lipid metabolism disorder linked with lipid accumulation within the arterial wall and subsequent formation of foam cells and vascular disease [96], [97]. The level of apelin is decreased in human atherosclerotic coronary arteries [4], and coronary collateral formation in

• HMGN proteins are subject to extensive post translational mo

  2025-02-24

  

  HMGN proteins are subject to extensive post-translational modifications which influence both their mode of binding to cdk9 inhibitor and their functional activity. Like the other HMG protein families, HMGNs are substrates for many of the same enzymes that modify histone proteins (review in [175]).

• br Concluding Remarks and Future Perspectives While

  2025-02-24

  

  Concluding Remarks and Future Perspectives While postmortem human H 89 material is relatively sparse and has inherent limitations as discussed above, additional investigations could benefit from analysis of in vitro cellular models to corroborate findings in patient material. Generation of neuron

• Further examination of these vmat IR cells shows that they

  2025-02-24

  

  Further examination of these vmat-IR cells shows that they are also positive for vimentin (vim-IR) (Fig. 3A). However, within any one cell there may be a region of weaker vmat-IR, suggesting sub-cellular localization. As also shown in Fig. 3B and C not all vim-IR cells are vmat-IR suggesting that th

• In pioneering work from Ikeda and

  2025-02-21

  

  In 2006, pioneering work from Ikeda and colleagues showed that GMF localizes to and regulates the rachel morin. cytoskeleton (see Glossary), and noted its sequence similarity to ADF/cofilin[11]. In 2009, the structure of GMF [6] was solved, revealing it to be a bona fide member of the actin depolyme

• Acknowledgements The work was supported by

  2025-02-21

  

  Acknowledgements The work was supported by grants from Swedish Research Council (J.Z.H.) (A.R.M.). We thank Protein Science Facility (PSF), Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden. We thank Prof. Ralf Morgenstern (Department for Environmental Medic

• Renal Cell Carcinoma RCC is a lethal cancer

  2025-02-21

  

  Renal Cell Carcinoma (RCC) is a lethal cancer with bad prognosis due to development of chemoresistance and recurrence of an aggressive tumor with increased tumor-angiogenesis and metastasis [7]. We have found Axl and Gas6 to be differentially presented in RCC subtypes, and Axl to correlate to tumor

• Previously several genes such as cytokine Lyu and

  2025-02-21

  

  Previously, several genes such as cytokine (Lyu and Park, 2007), cell motility-associated genes (Schotterl et al., 2017), transforming growth factor-β (TGF-β), TGF-β receptor II which is a cell surface receptor with serine/threonine kinase activity (Jiang et al., 2014, Schotterl et al., 2017), cell

• br The complementary role of chaperone mediated autophagy

  2025-02-21

  

  The complementary role of chaperone mediated autophagy Chaperone-mediated autophagy (CMA) mediates the degradation of specific cellular proteins and participates in the regulation of lipid metabolism, DNA repair, or the response to stress (Kaushik and Cuervo, 2018). CMA provides an alternative pa

• To clarify the molecular mechanism of maduramicin induced

  2025-02-21

  

  To clarify the molecular mechanism of maduramicin-induced apoptosis in chicken myocardial cells, the mRNA levels of bcl-2, bax, and cytochrome C, as well as the mRNA levels and activities of caspase-3/8/9 were determined. The mRNA expressions and activities of initiator casapase-9 and executioner c

• Therefore VEGF and its receptors are expressed in

  2025-02-21

  

  Therefore, VEGF and its receptors are expressed in different organs, including the kidneys, the liver and the 1-Oleoyl lysophosphatidic acid sodium salt [55]. In the human placenta, VEGF is mainly synthesized by cytotrophoblast and Hofbauer cells early in the first trimester, whereas Flk-1 and Flt-1

• Our conclusion was confirmed by two experiments The

  2025-02-20

  

  Our conclusion was confirmed by two experiments. The addition of aminopeptidase-specific inhibitors at high concentrations allowed us to exclude the possibility of substrate hydrolysis by other proteases present in the samples, for example, endoproteases. After the application of inhibitors, we were

• Although several studies indicate that ALDH protects

  2025-02-20

  

  Although several studies indicate that ALDH2 protects the heart from injury and maladaptive remodeling (reviewed in [11], [12], [13]), accumulating evidence indicates that deficiency of the enzyme could be protective as well. For example, mice expressing the defective Aldh2*2 mutation show lower ald

• Perhaps the discovery of this

  2025-02-20

  

  Perhaps the discovery of this linkage has served to catapult much of the work on ABCA1, leaving its family member in need of a relationship with a defined human pathology. In this regard, there is by now a quite mature literature that suggests that ABCA2 may have been overlooked in terms of its imp

• The rank order of agonist potency in turkey cardiac chambers

  2025-02-20

  

  The rank order of agonist potency in turkey cardiac chambers demonstrated the predominant presence of the β-adrenergic receptor subtype, in line with the receptor classification by . However, a previous radioligand binding study in the left ventricles of 7-week old turkeys reported the existence of

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