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br Transparency document br Acknowledgements This work was s
2019-08-14
Transparency document Acknowledgements This work was supported by research grant G092715N of the Research Foundation Flanders (FWO). The authors are indebted to Drs. V. Baekelandt and E. Lobbestael (Research Group for Neurobiology and Gene Therapy, KU Leuven) for stimulating discussions and he
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br Results with scrubbing process Based
2019-08-14
Results with scrubbing process Based on Triptolide discussion of Section 4.4 and area availability results of the previous section, scrubbing process, at the pixel processing rate, was included to mitigate error accumulation on the arrays and on the line-buffer. Eight sequential signals, plus the
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In the present study we
2019-08-14
In the present study, we have examined, an alternative approach for introduction of Hyp into bacterial, non-animal collagens. Previously, Gruskin and colleagues [27] had shown that Hyp could be introduced into recombinant mammalian collagen sequences in E. coli through a mechanism of co-translationa
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It has previously been shown that human melanocytes
2019-08-14
It has previously been shown that human melanocytes are responsive to a multiplicity of hormonal triggers [10], particularly to pituitary or ovarian hormones [11]. Studies concerning the effects of conotoxin in on human melanocytes led to inconsistent data [12], [13]. Im et al. [14] reported that th
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Methods br Results br Discussion It is well established
2019-08-14
Methods Results Discussion It is well established that CRSwNP is characterized by TH2 inflammation and eosinophilia.22, 27 Yet it is becoming increasingly apparent that B cells might play an important role in the inflammatory response within the sinus tissue of patients with CRSwNP.8, 9 The l
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br Significance Our understanding of the ubiquitin biology h
2019-08-14
Significance Our understanding of the ubiquitin biology has been rapidly expanding. The role of the ubiquitin system in the pathogenesis of numerous disease states has increased the interest in finding new strategies to pharmacologically interfere with the enzymes responsible of the ubiquitinatio
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br Materials and methods br Results
2019-08-14
Materials and methods Results Discussion The incretin hormones potently stimulate insulin secretion, and it is generally assumed that this is mediated by an endocrine mechanism such that GIP and GLP-1 through the circulation reach the islet beta chem 6 to stimulate their secretion. However
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Instead of introducing extra hardware or hardware modificati
2019-08-14
Instead of introducing extra hardware or hardware modification, software-based CFC techniques just insert extra checking instructions into the source code of the target program at compile time so as to have the target program do checking jobs itself. Preeminent software-based CFC techniques proposed
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br Conclusions In a former study we compared
2019-08-14
Conclusions In a former study we compared the modulating potential of halogenated 1H-benzimidazole derivatives towards CK2 catalytic subunits. Now we were interested if similar differences are also obtained using completely different substances. Some of these natural occurring compounds were alre
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br Materials and methods br Results
2019-08-14
Materials and methods Results Discussion Conclusions First, we replicated the association of DDR1 with SZ in an independent Spanish sample and demonstrated that a SNP-SNP interaction within DDR1 played a role in the association with the disease. Second, we observed that SZ subjects with
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Autophagy alterations are frequently reported as one of the
2019-08-14
Autophagy alterations are frequently reported as one of the pathological mechanisms contributing to neurodegenerative diseases, due to incomplete removal of protein FRAX486 in the brain [30,41]. It was over a decade ago when mutations in PARK8 encoding for the LRRK2 protein were described as a main
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br Conclusion In conclusion DNA methylation is a
2019-08-13
Conclusion In conclusion, DNA methylation is a major epigenetic mark, which regulates temporal and spatial expression of the testicular genes required for normal spermatogenesis process. There are two types of methylation, maintenance and de novo methylation, which are catalysed by DNMT1, DNMT3A
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Neutrophils produce high amounts of ROS which act as
2019-08-13
Neutrophils produce high amounts of ROS, which act as antimicrobial agents, signaling molecules or initiators during PMA-induced NET formation. Of the intravenous anesthetics used in this study, propofol was the best at decreasing PMA-induced ROS levels (Fig. 3A and B). Our previous study also demon
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Our recent discovery M P H R A
2019-08-13
Our recent discovery (M.P., H.R., A.S.) of a highly selective and in vivo active DDR1 small-molecule inhibitor provides evidence that DDR1 is a druggable pharmaceutical target, and some details of our efforts are provided below. To avoid the repurposing of known kinase inhibitor structural motifs, w
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In contrast to DDR the role
2019-08-13
In Caspase-3, human recombinant proteinase to DDR1, the role of oligomerization and/or clustering of DDR2 in mediating its interactions with collagen is less understood. Current data show that in DDR2, like in DDR1, (i) dimerization [7] and higher-order oligomerization of its ECD [11], [22] enhance
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