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br Declaration of interest br Funding
2024-04-16
Declaration of interest Funding Introduction The endocrine disruptor bisphenol A (BPA) is a high-production chemical used in several consumer products, including polycarbonate bottles, epoxy resins, dental sealants, and thermal paper receipts (Geens et al., 2012). Importantly, BPA monomers
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Besides Arg overexpression our data revealed
2024-04-16
Besides Arg2 overexpression, our data revealed that AGEs could decrease eNOS mRNA levels, which is considered a significant cause for attenuated NO production and vasodilation. It was found recently that AGEs significantly reduce eNOS expression levels and NO bioavailability in human carotid artery
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br Conclusions In the current study we found that the
2024-04-16
Conclusions In the current study, we found that the exposure of maduramicin to chicken myocardial Agarose GPG/LMP low melt synthesis results in cellular damage and even death via the induction of apoptosis. Maduramicin upregulated the expression of apoptotic genes and activated caspase cascades,
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br Conclusions The present protocol for
2024-04-16
Conclusions The present protocol for localizing or “spotting” the site of action of an antioxidant in a micro-heterogeneous medium is based on the differences in its reactivity vis-à-vis the series of amphiphobic TEMPO derivatives 1a–f. Plots of the relative antioxidant effectiveness of a given A
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Therefore a number of homoisoflavonoids may be designed
2024-04-16
Therefore, a number of homoisoflavonoids may be designed in future that may be effective against angiogenesis for treating ocular neovascularization. As this PLX4032 current study deals with robust molecular modeling techniques on SH-11037 (cpd 15) and related homoisoflavonoids and SH-11037 has gai
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The first and the best characterized mechanism of receptor d
2024-04-16
The first and the best-characterized mechanism of receptor-dependent internalization of Aβ is mediated via the α7-nicotinic Bioactive Compound Library receptor [82]. Lipoprotein receptor protein represents the second best-studied route that facilitates the uptake of Aβ by neurons, involving additio
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A large number of aldose reductase inhibitors
2024-04-16
A large number of aldose reductase inhibitors have been prepared synthetically, and a limited number of them are therapeutically used. However, none of them is satisfactory. Here, Cannabis extracts with high content of non-psychotropic phytocannabinoids CBD/CBDA or CBG/CBGA showed statistically sign
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Deferoxamine mesylate Cancers that responded to immune check
2024-04-16
Cancers that responded to immune checkpoint inhibitors were shown to present a type I interferon (IFN) signature in the TME 33, 34. Type I IFNs positively regulate the expression of tumor antigens and their crosspresentation by DCs to tumoricidal CTLs. Furthermore, CD8+ T cell develops full effector
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On the basis of the
2024-04-15
On the basis of the above information, we designed a new series of benzothiazole–piperazine derivatives (–) that have the aforementioned structural requirements (). Benzothiazole is an important ring system in the drug discovery studies of AD. There are several benzothiazole compounds that show pote
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Endoplasmic reticulum ER stress resulting
2024-04-15
Endoplasmic reticulum (ER) stress resulting from accumulation of misfolded proteins in ER lumen stimulates a chain of adaptive responses termed as the unfolded protein response (UPR). Glucose related protein (GRP78/BiP), key ER chaperone essential for the activation of the ER-transmembrane signaling
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br Conclusion br Acknowledgement This study was supported by
2024-04-15
Conclusion Acknowledgement This study was supported by NIH/NINDSR01 NS036812-16. Introduction Stroke is the leading cause of disability and the fifth leading cause of death in the United States (Writing Group et al., 2016). On average, every 4 min a human dies of stroke (Lackland et al., 2
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The accumulation of oxidized low density lipoprotein oxLDL
2024-04-15
The accumulation of oxidized low-density lipoprotein (oxLDL) is one of the many causes of the initiation and progression of atherosclerosis (Virmani et al., 2002; Pirillo et al., 2013; Sun et al., 2016; Huang et al., 2016; Tabas, 2010). oxLDL-induced apoptosis of macrophages contributes to the forma
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Dopaminergic neurons are vulnerable to oxidative products an
2024-04-15
Dopaminergic neurons are vulnerable to oxidative products and inflammatory responses; these processes may play important roles in the etiology of PD. Because glial TC 14012 receptor are the main generators of inflammatory responses in the CNS, the possibility that PD results from glial cell dysfunct
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br Other Strategies for HIF
2024-04-15
Other Strategies for HIF-α Inhibition NSC-644221 is another HIF-α inhibitor acting at the translational level, independently of proteasomal degradation and VHL status, and is devoid of DNA damage-inducing properties [70]. NSC-644221 arrests nuciferine in G2–M through a cell type-specific Topo-2-
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In addition enhanced AT receptor function abnormally
2024-04-15
In addition, enhanced AT1 receptor function abnormally increases central and sympathetic activity, contributing to cardiac and renal disease, which in turn alters homeostasis, increases vulnerability to stress, and further injures the brain, and that AT1 receptor blockade ameliorates excessive sympa
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