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Because of the lack of sequence current knowledge
2021-01-11
Because of the lack of sequence, current knowledge on the cellular regulation of CoA-IT is scarce. However, recent work has suggested an interesting new role for CoA-IT in regulating the extent of the AA mobilization response in primed macrophages. Bacterial lipopolysaccharide (LPS) is a poor trigge
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Circulating NK subsets also show considerable differences in
2021-01-11
Circulating NK subsets also show considerable differences in homing molecules. CD56bright bapta am mg express the chemokine receptor CCR7 and L-selectin, which drive their migration to secondary lymphoid organs (Fehniger et al., 2003). In contrast, CD56dim display a high density of CX3CR1 and CXCR1
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Erlotinib Hydrochloride synthesis One of the most fundamenta
2021-01-11
One of the most fundamental distinctions between Ub signals is substrate monoubiquitination versus polyubiquitination. With the exception of the E2, UBE2W, which represents a special case because it Erlotinib Hydrochloride synthesis only ubiquitinates the flexible N-termini of substrates [5], [6],
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br Enzymes involved in microbial steroid degradation are
2021-01-09
Enzymes involved in microbial steroid degradation are generally not expressed constitutively, but they are upregulated depending on which steroid substrates are present [17,81]. Thus, a cell-free extract prepared from testosterone-adapted C. testosteroni ATCC 11996 cells displayed a 1(2)-dehydroge
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The CysLT receptor antagonist BayCysLT
2021-01-09
The CysLT2 receptor antagonist BayCysLT2RA significantly suppressed multiple antigen challenge-induced infiltration of eosinophils and mononuclear Nucleozin into the lung, indicating that CysLT2 receptor activation is involved in leukocyte migration. In contrast to the present finding, Barret et al.
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This review focuses on the atomic basis
2021-01-09
This review focuses on the atomic basis of CRM1-mediated nuclear export. There are now 27 crystal structures of CRM1 in the Protein Data Bank (PDB) (www.rcsb.org) [64]. Collectively, this large body of work explains various aspects of CRM1 function. Here we summarize the structure–function studies t
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Progesterone s metabolite THP may also be mediating burying
2021-01-09
Progesterone's metabolite, 3α,5α-THP, may also be mediating burying and freezing responses. Results show female Long–Evans rats in behavioral estrous have higher P4 levels in serum, 84 and hippocampus compared to diestrous female Long–Evans rats. Additionally, ovx female Long–Evans rat administered
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We then analyzed Ki proliferation index as a
2021-01-09
We then analyzed Ki-67 proliferation index as a categorical variable by using 15%, essentially the median Ki-67 value in the entire study group (see above), to delineate low and high proliferation subgroups. By Fisher's exact test, both the type 1 versus non-type 1 EWS-FLI1 comparison (P = 0.047; Ta
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br STAR Methods br Microenvironmental niches for na
2021-01-09
STAR★Methods Microenvironmental niches for naïve and activated B cells Secondary lymphoid organs, such as the spleen and lymph nodes, are structurally and functionally compartmentalized to provide a set of microenvironmental niches that support the survival of resting B cells, as well as the a
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In pregnancy maternal uterine spiral artery SA remodeling is
2021-01-09
In pregnancy, maternal uterine spiral artery (SA) remodeling is essential for ensuring efficient blood flow to the developing fetus. A subset of CD49a+Eomes+ decidual NK PFI 3 (dNK) that actively secretes GFs, such as pleiotrophin and osteoglycin, have recently been described in humans and in mice.
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Breast cancer is the most common neoplasm
2021-01-09
Breast cancer is the most common neoplasm in women, with approximately 231,840 new cases of invasive breast cancer, 60,290 additional cases of in situ breast cancer and 40,290 deaths occurring in 2015 in the United States. Meanwhile, about 2350 men will be diagnosed with breast cancer, and 440 men w
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br Materials and methods br Results br Discussion We found
2021-01-09
Materials and methods Results Discussion We found that mRNA expression of PCNA significantly was down-regulated in BCP-ALL NECA following co-treatment with doxorubicin and NU7441 (Fig. 6e). Our result is congruent with Gehen et al. study reporting that down-regulation of PCNA potentiates g
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br Mammalian DGKs current knowledge Despite our understandin
2021-01-09
Mammalian DGKs: current knowledge Despite our understanding of prokaryotic DGKs, our limited understanding of the structure of mammalian DGKs is a major gap in our knowledge. Importantly, major differences exist between prokaryotic and mammalian enzymes often revealing the fact that structural fe
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We have previously characterized the leucine rich
2021-01-08
We have previously characterized the leucine-rich NESs located within the zinc-binding domains of mucosal high risk HPV16 E7 (76IRTLEDLLM84) and low risk HPV11 E7 (76IRQLQDLLL84) mediating their nuclear export in a CRM1 dependent manner (Knapp et al., 2009, McKee et al., 2013). The zinc-binding doma
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Besides the enhanced expression of costimulatory and
2021-01-08
Besides the enhanced expression of costimulatory and adhesion proteins, also the expression of the CD83 surface molecule is strongly enhanced during DC maturation (Banchereau and Steinman 1998; Banchereau et al. 2000). In fact, CD83 is a major cell surface marker for fully mature DC, as it can not b
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