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br Overall system architecture In this section we provide a
2021-04-25
Overall system architecture In this carboxypeptidase a section we provide a description of the system under study, and its surrounding environment, on an “as is” basis. The architecture presented in the following is the one currently adopted on-field by ASTS (e.g., at Rome train station). The T
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Although MMP might be a downstream target of
2021-04-25
Although MMP-9 might be a downstream target of Src kinase signaling (Liu and Sharp, 2011), a direct connection has not been established. We showed for the first time that, in the collagenase-induced ICH model, Src kinase signaling regulates MMP-9 activity and mediates EP1R toxicity. Consistent with
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Cystatins are potent inhibitors of cysteine
2021-04-23
Cystatins are potent inhibitors of cysteine proteases from the C1A family. These inhibitors primarily reduce the activities of cathepsin L-like proteases, although high concentration of barley cystatin hampers the degradation of storage proteins caused by cathepsin F-like protein (HvPap-1) (Cambra e
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The early serologic response of infants
2021-04-23
The early serologic response of infants to infection with HIV-1 is obscured by the presence of transplacentally acquired maternal HIV antibody. However, the HIV STK393606 mg produced in vitro by peripheral blood from infants has been studied (Pollack et al., 1993) and it has been shown that neonata
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br Data deposition The structure
2021-04-23
Data deposition: The structure factor amplitudes and coordinates of mIL34 and the mIL-34:mCSF-1R complex have been deposited in the Protein Data Bank, www.pdb.org, with accession codes 4EXN and 4EXP. Note added in proof The authors would like to inform the readers of two recent articles that are
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We have previously characterized the leucine rich NESs locat
2021-04-23
We have previously characterized the leucine-rich NESs located within the zinc-binding domains of mucosal high risk HPV16 E7 (76IRTLEDLLM84) and low risk HPV11 E7 (76IRQLQDLLL84) mediating their nuclear export in a CRM1 dependent manner (Knapp et al., 2009, McKee et al., 2013). The zinc-binding doma
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br Experimental section br Results
2021-04-23
Experimental section Results Discussion In our previous work (Rashidi et al., 2018) we isolated a novel glucarpidase whose raised endothelin receptor antagonist did not cross-react with the one in clinical use. In principle, therefore, it would be possible to delay the production of antibo
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Yang et al investigatedPsoralidin a
2021-04-23
Yang et al. investigatedPsoralidin 39, a coumestan derivative isolated from the seed of Psoralea corylifolia, regarding its effects on IR-induced pulmonary inflammation. Psoralidin 39 inhibited the IR-induced COX- 2 expression and PGE(2) production through regulation of PI3K/Akt and NF-κB pathway. A
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br Materials and methods br Results br Discussion
2021-04-23
Materials and methods Results Discussion One novel finding in our study is that CK2 inhibition preserved axon function and structure in WM against ischemia. Consistent with these findings, oligodendrocytes, astrocytes, myelin, and muscle metabolism were found to express CK2α. The robust ex
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In S cerevisiae Mek a paralog of
2021-04-23
In S. cerevisiae, Mek1, a paralog of the checkpoint kinase Chk2, mediates cell-cycle arrest in response to meiotic defects (Bailis and Roeder, 2000, Xu et al., 1997). Mek1 is associated with meiotic chromosome axes, where its activation requires interactions with two other axis proteins, Hop1 and Re
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Soon after the discovery of ET
2021-04-23
Soon after the discovery of ET1 and the cloning of its ETA and ETB receptors, low-molecular-weight compounds were identified that can prevent the binding and effects of radioactively labeled ET1 3, 5, 6, 8. Initially, these ERAs resulted from screening efforts (e.g. BQ123 39, 49 and bosentan [50]).
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br Materials and methods br Results br
2021-04-23
Materials and methods Results Discussion A reporter of FGF signaling activity has long been sought to facilitate the quantitative real-time analysis of pathway activity at single-cell resolution. Here we report the generation of a Spry4 reporter allele in ESCs and mice that recapitulates kn
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We report our experience using
2021-04-23
We report our experience using conventional cytogenetic analysis, FISH using EWSR1 break-apart probes, RT-PCR, and Sanger sequencing to detect characteristic translocations in a total of 32 patients with ES diagnosed at Texas Children's Hospital over a 5-year interval. Materials and methods Re
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obatoclax The transcription factor CREB has been extensively
2021-04-23
The transcription factor CREB has been extensively studied for its role in hippocampus-dependent learning and memory (West et al., 2002, Lonze and Ginty, 2002). Previous research has demonstrated that the phosphorylation of CREB at Ser133, performed by the ERK1/2 signaling pathway, initiates a casca
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AI-10-49 br Conflict of interest statement br
2021-04-23
Conflict of interest statement References and recommended reading Papers of particular interest, published within the period of review, have been highlighted as: Acknowledgements We acknowledge financial support by the Swiss State Secretariat for Education, Research and Innovation (Federal
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