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In comparing the amounts of
2021-10-18
In comparing the amounts of total GST activity of the rabbit cornea, porcine cornea and Hemicornea construct (Fig. 4A), the construct was found to exhibit an obviously lower level of GST activity. To assess these findings, it excuse will be necessary to compare them to the level in the human corne
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LPCs have been previously described as potential
2021-10-18
LPCs have been previously described as potential anti-diabetic factors due to stimulation of secretory activity from the isolated rodent pancreas, L-type cells, ands insulin-producing cell lines, with LPC 18:1 as the main structure of interest (Soga et al., 2005, Sakamoto et al., 2006, Overton et al
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In this study we describe the role of a specific
2021-10-18
In this study, we describe the role of a specific species of LPI in the secretion of GLP-1 from enteroendocrine L-cells and primary cell preparations. We further demonstrate the specific role of GPR119 in LPI-dependent GLP-1 secretion. To achieve this, we downregulated GPR119 and GPR55 protein expre
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ML-265 synthesis Introduction CD T cell recovery after initi
2021-10-18
Introduction CD4+ T cell recovery after initiation of combination antiretroviral therapy (cART) is essential for restoring immune function in HIV-positive individuals [1]. However, CD4 recovery is variable and is affected by factors such as biological sex [2], [3], race [4], BMI [5], geographic reg
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In mammals the primary cilium
2021-10-18
In mammals, the primary cilium is considered a hub for signal transduction. The cilium has previous been associated with transduction of several pathways including Wnt (Corbit et al., 2008, McDermott et al., 2010, Tran et al., 2014), PDGF (Clement et al., 2013, Schneider et al., 2010, Schneider et a
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With the nitrogen containing heterocycle components and
2021-10-16
With the nitrogen-containing heterocycle components and the acidic components in hand, the final products were synthesized according to the procedure as depicted in . Reaction of – with various β-substituted phenylpropionic glibenclamide (, and ), followed by deprotection by TFA, smoothly provided
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The Hippo pathway has been well established
2021-10-16
The Hippo pathway has been well established as a tumor suppressor pathway and is involved in many diverse biologic processes including cell growth, cell death, and organ size control in organisms, ranging from Drosophila to mammals [4]. Central to this pathway is a kinase cascade in which the Ste20-
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We compared the mixotrophic growth of mutant DRHB and the
2021-10-16
We compared the mixotrophic growth of mutant DRHB1486 and the wild-type at different light intensities. The mutant grew at a similar rate as the wild-type at a low light intensity but much more slowly at a high light intensity (Fig. 3). Because the slr2094 mutant was unable to grow under photoautotr
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br Acknowledgments R Dalmann has obtained a bourse
2021-10-16
Acknowledgments R. Dalmann has obtained a “bourse Cifre” (grant 304/2011) from the ‘Association Nationale de la Recherche Technique’ and Bristol-Myers-Squibb. Introduction Endocannabinoids, their molecular targets (receptors), their synthetic and degrading enzymes and proteins that transport
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The effect of combined A and PD
2021-10-16
The effect of combined A-192621 and PD 155080 treatment on the racecadotril australia during endotoxin infusion is quite different compared to either drug used alone (Wanecek et al., 1999). After administration of both antagonists in combination, cardiac index increased to baseline values within 30
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br Discussion Considering cardiovascular risk factors there
2021-10-16
Discussion Considering cardiovascular risk factors, there was a significant difference in prevalence of dyslipidemia in both groups, 57.5% in HIV-infected stroke patients compared to 8.9% in the HIV-uninfected patients. These results are similar to that of Chow et al. who found a dyslipidemia pre
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In the adult normal spinal cord the resident
2021-10-16
In the adult normal spinal cord, the resident cells mainly include neurons, astrocytes, oligodendroglia and microglia (Lecca et al., 2012, Miyagi et al., 2012). After SCI, the lesion microenvironment is complex, which includes the functional changes of CNS resident cells and the infiltration of leuk
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Studies have demonstrated the paradoxical
2021-10-16
Studies have demonstrated the paradoxical role of HO-1 in tumorigenesis. At initial stages of carcinogenesis, it protects DNA by lowering the ROS-mediated mutational rate, but later, HO-1 promotes cancer cell survival and proliferation. One PDAC therapeutic strategy is to increase ROS production and
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4-DAMP Introduction Cancer has been a significant public hea
2021-10-16
Introduction Cancer has been a significant public health problem in the world with more patients being diagnosed every year. However, chemotherapy from non-specific cytotoxic agents that as an effective means of cancer treatment is limited by severe side effects and poor selectivity. Thus, the deve
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Amelogenesis is a complicated process as described
2021-10-16
Amelogenesis is a complicated process, as described above, and for the last several decades, various animal and human studies have used molecular genetics to identify a number of signaling molecules and gene networks that act at specific stages of the ameloblast life cycle and regulate its patternin
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