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Insulin de sensitization has been observed in the
2021-12-24
Insulin de-sensitization has been observed in the brains of people with AD [51], [52], [53] and we previously demonstrated that the GLP-1 analogue liraglutide was able to reverse this [54]. Importantly, Wortmannin insulin de-sensitization correlates well with cognitive decline [15], [55] and with t
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Among sensitizers tested in the previous study
2021-12-23
Among 22 sensitizers tested in the previous study, six test chemicals were pre- or pro-haptens (Nepal et al., 2018a). Among 6 chemicals, hydroquinone and 2-aminophenol, strong sensitizers, were falsely classified as non-sensitizers due to the lack of metabolic activation (Nepal et al., 2018a). Liter
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The present data suggest that the decrease of liver
2021-12-23
The present data suggest that the decrease of liver BAs was mainly due to the decrease of hepatic BAs synthesis because the BA synthetic enzymes Cyp7a1, Cyp7b1 and Cyp8b1 were markedly reduced. The increase may also be due to the increase of hepatic BAs efflux, because the liver BA efflux transporte
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Despite such extensive analysis of Gcn homologs the
2021-12-23
Despite such extensive analysis of Gcn5 homologs, the function of C. albicans Gcn5 (CaGcn5) is not well understood. Therefore, in this study we investigated the role of CaGcn5 in filamentous growth, invasive growth and stress response of C. albicans. We also examined the subcellular distribution of
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With the administration of OM fatty acids
2021-12-23
With the administration of OM3 fatty acids, it has previously been shown that the activation of GPR120 is linked to the secretion and circulating levels of the adipokine adiponectin [123] promoting anti-inflammation (downregulation of NF-κB) and insulin sensitivity [124]. Interestingly, Nrf2 also de
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The activation of the ERK pathway participates
2021-12-23
The activation of the ERK pathway participates in the transmission of pain signaling by sensitizing primary afferents (Ji et al., 2009, Lai et al., 2011). Thus, the blockade of ERK activation in the primary sensory PI103 australia can reduce the mechanical hypersensitivity and the thermal hypersens
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br Materials and methods br Results br Discussion Nervous sy
2021-12-23
Materials and methods Results Discussion Nervous system disease is an important signal of AIDS deterioration (Rosca et al., 2012, Yilmaz et al., 2012). It is possible that HIV crosses the blood Saracatinib sale barrier or blood cerebrospinal fluid barrier into the central nervous system fr
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As our earlier study investigated glut mRNA levels in respon
2021-12-23
As our earlier study investigated glut mRNA levels in response to a protein load contained in a meal and the studies that used glucose and insulin injections did not examine GLUT expression, this study sought to investigate the effects of hyperglycaemia and insulin on mRNA levels in the spiny dogfis
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Epinephrine responses to hypoglycemia are probably triggered
2021-12-23
Epinephrine responses to hypoglycemia are probably triggered centrally, perhaps with input from peripheral hypoglycemia sensing [3], [4]. We observed increased epinephrine responses in GCK-MODY and I366F diabetic mice. Consistent with a role for Canagliflozin GCK in detecting a low blood glucose, w
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Thus this work aims to evaluate the effect of tannic
2021-12-23
Thus, this work aims to evaluate the effect of tannic 2-Deoxyadenosine 5-diphosphate on β-galactosidase activity, by observing the variations in the molecular interaction kinetic parameters ( and ). Besides, these data were correlated with the modifications that the tannin caused to the enzyme’s se
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br Materials and methods br
2021-12-22
Materials and methods Results Discussion It is known that MAPKs and Akt signaling can regulate cell migration [[24], [25], [26]]. In this study we found that dTAT-WKYMVm stimulates ERK, p38 and Akt phosphorylation in naïve CD4 T cell (Fig. 3A). However their activation did not affect naïve
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Computational approaches such as docking and classical molec
2021-12-22
Computational approaches such as docking and classical molecular dynamics (MD) are now commonly used to study the structure and dynamics of proteins as well as associated protein-ligand interactions [12]. A fundamental requirement of MD in order to accurately determine the behavior of a protein over
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SCH is a H R receptor antagonist
2021-12-22
SCH-497079 is a H3R receptor antagonist introduced by Schering-Plough, without any publicized pharmacological and structural information. A Phase II clinical trial assessment of SCH-497079 on weight has been completed in a multicenter, randomized, parallel-group and placebo-controlled study in obese
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nop receptor The two competitive bivalent GlxI inhibitors po
2021-12-22
The two competitive bivalent GlxI inhibitors polyBHG2-62 (=1nM) and polyBHG2-54 (=0.3nM) () were designed based on the transition-state analog -(-bromophenyl--hydroxycarbamoyl) glutathione (BHG) by an examination of the X-ray crystal structure of human GlxI in complex with one CHG at each active sit
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Crystal structures from soluble E
2021-12-22
Crystal structures from soluble E2 constructs (Khan et al., 2014; Kong et al., 2013) have revealed globular protein with no regular structure in spite of having eight disulphide bonds (Kong et al., 2013). Although 62% of the protein exists in loops or disordered structures, overall it was well-defin
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