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In conclusion we demonstrate for the first
2022-05-06
In conclusion, we demonstrate, for the first time, that histamine plays a key role in regulating astrocyte function and gliotransmitter release, and we now must re-consider the roles of monoamine neurotransmitters in brain function in the context of astrocyte signalling. Further in vivo studies will
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br Conclusion br Acknowledgement br Introduction Biogenic am
2022-05-06
Conclusion Acknowledgement Introduction Biogenic amine histamine is synthesized from L-histidine by histidine decarboxylase (HDC). Histamine is involved in a wide variety of pathological and physiological processes including allergic reactions, inflammation, immune responses, gastric secret
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Here we examine the impact of hypoxia on
2022-05-06
Here we examine the impact of hypoxia on lake whitefish (Coregonus clupeaformis) during embryonic and larval development. Lake whitefish are a cold-water salmonid endemic to North America and are found from western Alaska, USA to eastern Labrador in Canada. Spawning occurs from late autumn to early
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Importantly HDACi mediated effects are cell and
2022-05-06
Importantly, HDACi-mediated effects are cell and HDAC specific; different effects and outcomes have been observed in different cell types, targeting different HDAC isoforms. While HDACi exhibit a strong proapoptotic potential in human leukemia pdk1 19, 20, 21, 22, they have a limited ability to ind
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br Effect http www apexbt
2022-05-06
Effect of HDACi on Proteasomal Regulation of IκBα and p65 Levels At the transcriptional level, expression of CXCL8, as well as many other proinflammatory chemokines, is regulated by the transcription factor NFκB, which is constitutively activated in solid cancers, including OC, lung, and breast c
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In summary P P macrocyclization proved to be
2022-05-06
In summary, P2-P4 macrocyclization proved to be an effective strategy to drive activity in this series of HCV NS3 protease inhibitors while microsomal stability was enhanced by the introduction of steric bulk along the tether. This modification augmented the previously-described tactic of improving
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It is known that changes
2022-05-06
It is known that changes in cGMP levels are positively correlated with plant adaptation to environmental stresses. It seems that a novel group of moonlighting kinases with GC activity is particularly involved in response to biotic stress. It was shown that danger-associated molecular pattern (DAMPs)
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One important aspect about GSK
2022-05-06
One important aspect about GSK-3 inhibitors is their effect on pluripotency of 5z [4]. Many GSK-3 inhibitors are ATP-competitive and suppress both GSK-3alpha and GSK-3beta [476]. BIO was shown to suppress GSK-3 activity and promote Wnt/beta-catenin signaling. This combination of events preserved th
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Bupivacaine is one of the local
2022-05-06
Bupivacaine is one of the local anesthetics commonly used in spinal anesthesia. Previous studies had shown that bupivacaine induced neuronal apoptosis and axon degeneration among various neuronal populations in spinal cord, such as sciatic nerves and dorsal root TCS HDAC6 20b synthesis (DRG) neuron
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Apart from the different assays used biased agonism could
2022-05-06
Apart from the different assays used, biased agonism could also explain the inconsistent pharmacology of GPR55. Indeed, one study compared the effect of LPIs and Virodhamine in HEK293 cgrp stably transfected with human GPR55. They found that the effect of both ligands on intracellular Ca2+ was bloc
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Consistent with previous reports of
2022-05-06
Consistent with previous reports of an association between increased accumulation of cAMP and GLP-1 secretion [25, 44, 45], we hypothesized that Oleoyl-LPI may regulate GPR119 activation and secretion of GLP-1 secretion through the cAMP/PKA/CREB pathway. Pharmacological inhibition of PKA by H-89 was
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br Results br Discussion Cell contact
2022-05-06
Results Discussion Cell-contact-mediated spread of HIV-1 has been estimated to be at least an order of magnitude more efficient compared to passive dissemination of particles through the extracellular milieu. Thus, this form of viral transmission can have significant effects on the pathogenesi
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Adenosine triphosphate ATP is thought to
2022-05-06
Adenosine triphosphate (ATP) is thought to be a crucial molecule in acute pain signaling in the DRG, as well as in the development and maintenance of chronic pain (Burnstock, 2009, Burnstock, 2013, Burnstock, 2014, Chizh and Illes, 2001). Extracellular ATP activates the ionotropic P2X receptors (Bur
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In contrast to UDG SMUG
2022-05-06
In contrast to UDG, SMUG1 exhibits dramatically lower product yield in its excision of U, and this is not dependent on sequence context. Though we cannot rule out that a small amount of the product is derived from a duplex contaminant, our extensive purification techniques limit the amount of contam
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Histamine functions as a key neurotransmitter in multiple ci
2022-05-06
Histamine functions as a key neurotransmitter in multiple circuits to control various behaviors. In Drosophila photoreceptor, AZD-9291 sale is produced de novo by histidine decarboxylase (Burg et al., 1993); meanwhile, maintaining normal histamine content also depends on the histamine recycling pat
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