Archives
- 2018-07
- 2018-10
- 2018-11
- 2019-04
- 2019-05
- 2019-06
- 2019-07
- 2019-08
- 2019-09
- 2019-10
- 2019-11
- 2019-12
- 2020-01
- 2020-02
- 2020-03
- 2020-04
- 2020-05
- 2020-06
- 2020-07
- 2020-08
- 2020-09
- 2020-10
- 2020-11
- 2020-12
- 2021-01
- 2021-02
- 2021-03
- 2021-04
- 2021-05
- 2021-06
- 2021-07
- 2021-08
- 2021-09
- 2021-10
- 2021-11
- 2021-12
- 2022-01
- 2022-02
- 2022-03
- 2022-04
- 2022-05
- 2022-06
- 2022-07
- 2022-08
- 2022-09
- 2022-10
- 2022-11
- 2022-12
- 2023-01
- 2023-02
- 2023-03
- 2023-04
- 2023-05
- 2023-06
- 2023-07
- 2023-08
- 2023-09
- 2023-10
- 2023-11
- 2023-12
- 2024-01
- 2024-02
- 2024-03
- 2024-04
- 2024-05
- 2024-06
- 2024-07
- 2024-08
- 2024-09
-
br Results and discussion GSTP
2022-06-28
Results and discussion GSTP1 is a Phase II cytoprotective and detoxifying enzyme. Due to its role in the detoxification of numerous endogenous and exogenous chemical agents (with electrophilic functional groups), individuals with Ile105Val mutation in this gene show enhanced risk of atopic disord
-
The lactic acid receptor HCA is primarily expressed
2022-06-28
The lactic Penciclovir Sodium receptor HCA1 is primarily expressed in white and brown adipocytes 11, 12, 17, 18 (Table 1). Only relatively low expression levels of HCA1 have been described in several other tissues 16, 19, and it is not clear whether this is due to the presence of adipocytes in thes
-
Ning et al showed that LPC appeared to increase
2022-06-28
Ning et al. showed that LPC 18:1 appeared to increase insulin release through both GPR119-dependent and -independent mechanisms (Ning et al., 2008). In our study, we have shown that not only GPR119 but also GPR40 and GPR55 participate in LPC-stimulated insulin secretion (Fig. 4, Fig. 5) and target p
-
br Materials and methods br Results
2022-06-27
Materials and methods Results Discussion Defective regulation and inappropriate activation of the HH signaling pathway is implicated in many cancers. SMO targeting inhibitors were the first to enter clinical trials, however complications with acquired resistance and toxicity, also exemplifi
-
It is generally considered that elevated blood glucose
2022-06-27
It is generally considered that elevated blood glucose due to insulin resistance is an important factor in islet compensation to high fat feeding [27]. However, we have shown recently that insulin resistance induced in mice by hydrocortisone injection provokes significant islet U 46619 in the absenc
-
In summary the SAR of a series of
2022-06-27
In summary, the SAR of a series of phenylpropanoic acid-free fatty parp receptor agonists is described which resulted in the identification of potent FFA4 agonists. The superior pharmacokinetic properties of compound led to its selection as an in vivo tool compound which afforded robust efficacy in
-
172 5 sale As a part of our continuing efforts
2022-06-27
As a part of our continuing efforts towards discovery of new class of compounds against different therapeutic areas and based on the literature reports, we designed a dual pharmacophore which possess a long aliphatic chain of free fatty acids and a phenyl propanoid part of known GPR40 agonists. Here
-
Platycodon grandiflorum is a member
2022-06-27
Platycodon grandiflorum is a member of the genus Platycodon and is commonly known as balloon flower. In East Asia, P. grandiflorum is used for the treatment of asthma, coughs, inflammatory diseases, pulmonary tuberculosis, and diabetes (Takagi and Lee, 1972). Furthermore, recent studies have reporte
-
In contrast the sGC activator BAY relaxed the CC in
2022-06-27
In contrast, the sGC activator BAY 58-2667 relaxed the CC in a concentration-dependent manner (Figure 4B), a response that was significantly increased in the CC of sGCβ1ki/ki mice compared with WT mice. The finding that BAY 58-2667 also possessed a corporal relaxing effect in WT mice is suggestive
-
Introduction In the s nitric oxide NO was first characterize
2022-06-27
Introduction In the 1980s, nitric oxide (NO) was first characterized as critical to both innate immunity and endogenous signaling in animals [[1], [2], [3], [4], [5]]. NO was the first gaseous signaling molecule synthesized by animals to have its biochemical signaling pathway fully described [2]. P
-
Cells undergoing EMT display a downregulation of
2022-06-27
Cells undergoing EMT display a downregulation of E-cadherin and dissociation of their junctional complexes that associates cell-cell contacts with the SMER 3 australia cytoskeleton, known as the adherens junction (Berx and van Roy, 2009, Birchmeier and Behrens, 1994). Adherens junctions are special
-
br Materials and methods br Results
2022-06-27
Materials and methods Results As expected, due to matching by age, the mean ages were similar for the two groups of children when stratified by ASD status; children with an ASD had a mean age of 67.0 months, while the mean age for children in the TD control group was 68.0 months. Nearly all of
-
To apply the recently developed GPR ligands
2022-06-27
To apply the recently developed GPR35 ligands to CNS disorders, it is necessary to understand whether GPR35 is expressed by any identified cell types in the DAPTinhibitor and whether activation or blockade of this receptor has any consequence on the activity of the neuronal circuitry. To this end, t
-
Here we reported series of carbohydrate modified compounds
2022-06-24
Here, we reported series of carbohydrate-modified compounds containing a dibromo substituted benzene ring which was derived from the red alga (). The conformation flexibility of Sometimes and their polyol structures give them many unique biological properties as we have described earlier. More int
-
In general fish has a
2022-06-24
In general, fish has a limited ability for digestion and metabolism of carbohydrate though carbohydrate is the cheapest dietary energy and carbon source to animals and the best candidate for replacing dietary protein (Enes et al., 2009, Kamalam et al., 2017, Wilson, 1994). Furthermore, the analysis
14592 records 319/973 page Previous Next First page 上5页 316317318319320 下5页 Last page