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Our supF forward mutation assay revealed for the
2022-09-16
Our supF forward mutation assay revealed, for the first time, that 5OHU predominantly induced the C→T mutation in human cells. The mechanism underlying the induction of the C→T mutation in human cells by 5OHU remains unclear, however, the finding that 5OHU predominantly induced the C→T mutation was
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In conclusion we demonstrated that the atypical high
2022-09-16
In conclusion, we demonstrated that the atypical high-basal activity of the mGlu3 bioactive mg results mostly from its activation by low ambient glutamate concentrations. This is due to a unique interaction network located in the extracellular domain of the mGlu3 receptor. This network acts as “Cl−
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This study was approved by our institutional ethics committe
2022-09-16
This study was approved by our institutional ethics committee, and informed consent was obtained from each participant or legal guardian. We performed whole-genome SNP genotyping in the one unaffected and two affected siblings by using the Illumina Human 610 Genotyping BeadChip panel, which interrog
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The bioconversion of inositol from glucose was anticipated
2022-09-16
The bioconversion of inositol from glucose was anticipated nearly a century ago and later confirmed by isotope tracing methods [[22], [23]]. This biosynthesis of inositol involves three sequentially acting enzymes: Firstly, ATP-dependent glucokinase converts glucose to glucose-6-phosphate (G-6P) [[2
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It was previously proposed that glucagon
2022-09-16
It was previously proposed that glucagon acts in the liver, in which a signal is produced and relayed to the AP1903 via vagal nerves [8], [36], [37]. The concept that the liver is the primary target site was supported by the studies reporting that the glucagon receptor is localized in the liver but
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We have previously shown in the same time
2022-09-16
We have previously shown in the same time frame reported here (10 min) that AG was not degraded into DAG [29] and that the half-life of AG in human serum is ∼10 min [49]. However, we cannot rule out in this study that there is not breakdown to DAG that could contribute to the levels of 125I-ghrelin
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br Conclusions We concluded that the inhibitory
2022-09-15
Conclusions We concluded that the inhibitory effects of propofol on fMMYALF-induced neutrophil activation are mediated by competition with FPR1, which inhibits receptor-mediated downstream signaling and inflammatory responses such as oxidative burst, elastase release, and chemotactic migration (F
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We detected the FFAR protein
2022-09-15
We detected the FFAR2 protein with a molecular mass of about 50 kDa, which is comparable to the main band detected in pigs (Li et al., 2014) but different from the calculated size based on the sequence (Wang et al., 2009). The size difference can be explained, at least in part, by glycosylation site
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Consistently with the above discoveries it has
2022-09-15
Consistently with the above discoveries, it has been also shown that in cardiomyocytes with shRNA-down-regulated FBP2, mitochondria are more susceptible to depolarisation (Gizak et al., 2012a) and H2O2-induced oxidative stress (Wiśniewski et al., 2017). In trans-AUCB overexpressing FBP2 (cardiomyocy
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In the FARM motifs of GGPPSs hydrophobic amino
2022-09-15
In the FARM motifs of GGPPSs, hydrophobic JNJ-10198409 are replaced by aliphatic amino acids, which are more flexible residues and allow the entrance of longer substrates into the pocket (Wang and Ohnuma, 2000). It has been reported that the lepidopteran Manduca sexta CA possesses GGPP synthase (GG
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The suboptimal trypsin selectivity profile of DPC p http
2022-09-15
The suboptimal trypsin selectivity profile of DPC423 prompted us to investigate additional P moieties for potency and selectivity. Glycinamide P () showed low nanomolar binding affinity against fXa which suggested that this P moiety sits deeper into the S pocket of fXa. To further elaborate on this
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Introduction Thrombotic disorders including ischemic heart d
2022-09-15
Introduction Thrombotic disorders including ischemic heart disease, deep venous thrombosis, and ischemic stroke represent one of the most common causes of death in the world [1]. All these conditions relate to states accompanied by a shift of hemostasis balance into a coagulation side because of va
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In conclusion a series of new carboxamido
2022-09-15
In conclusion, a series of new 3-carboxamido-5-aryl-isoxazoles was designed, synthesized and screened for their inhibitory potency against FAAH. Their cytotoxicity was determined and their lipophilicity was calculated. Compounds bearing a 3-substituted biphenyl moiety with high Log values displayed
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In addition to Rabs several proteins have
2022-09-15
In addition to Rabs, several proteins have been shown to interact with Rabphilin3a, for instance the GluN2A subunit of the NMDA receptor, PSD-95 ([56,57] and references therein), Rabaptin-5, α-actinin [16] and SNAP-25 [21,23,41,61]. Only the latter has been reported to participate in the AR. Explori
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Superoxide Dismutase (SOD) Activity Assay Kit The IN gene of
2022-09-15
The IN gene of the HIV isolate from Papua (CRF01_AE isolate) contains genetic polymorphisms (Fig. 1A) that encode for variant amino acids in the IN protein, based on the Stanford HIVdb mutation interpretation database (Fig. 1B). These variations slightly changed the three-dimensional structure of IN
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