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Thus one possible target for CRPC treatment is the
2023-03-03
Thus one possible target for CRPC treatment is the enzyme 17,20-lyase, which plays a crucial role in androgen biosynthesis. This is because inhibition of 17,20-lyase would be expected to decrease serum androgen levels secreted not only by the testes but also by the adrenal glands.7, 8, 9 In recent
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br Acknowledgment br Introduction The yeast Cdc ATPase
2023-03-03
Acknowledgment Introduction The yeast Cdc48 ATPase and its metazoan ortholog p97 (or VCP) are critical components of many ubiquitin-dependent cellular pathways that require the segregation of individual proteins from binding partners or membranes (for review, see Buchberger, 2013, Meyer and We
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NVP-LAQ824 receptor ATM is generally regarded to be
2023-03-03
ATM is generally regarded to be the principal mediator of the G1 NVP-LAQ824 receptor checkpoint, whereas the induction of the intra-S-phase and G2/M checkpoints are usually primarily related to ATR function. However, several studies have demonstrated that, depending on the cellular context and type
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br Acknowledgment Supported in part by NIH
2023-03-03
Acknowledgment Supported in part by NIH1R21EB012707 (Biegon, Anat PI). Introduction Estrogens exert pleiotropic effects on a variety of morphological, physiological and behavioral responses in all vertebrate classes ranging from fishes to mammals. Effects of estrogens in the LY2784544 mg conc
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There are in contrast many studies demonstrating that
2023-03-03
There are in contrast many studies demonstrating that sex steroids modulate TOK-001 processing of stimuli related to reproduction and this correlates with the observation that steroid receptors and aromatase are expressed in many brain nuclei that are part of the olfactory, visual and auditory path
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br Materials and methods br Results br
2023-03-03
Materials and methods Results Discussion I/R injury is characterized by myocardial damage triggered by the ischemic insult followed by reperfusion injury. While the primary insult depends mainly on the severity and duration of blood flow restriction and the breakdown of ATP-dependent NU 702
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Several MAP kinases are involved in the
2023-03-03
Several MAP kinases are involved in the signal transduction pathways that lead to the upregulations of inflammatory mediators. Moreover, transcriptional activations of STATs are regulated by MAP kinases, as evidenced by reports that p38 MAPK is necessary for the S727 phosphorylation of STATs (Kovari
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br Materials and methods br Results and discussion br
2023-03-02
Materials and methods Results and discussion Conclusion Introduction Free radicals produced by normal oxidative metabolism in the human body can cause chain oxidation of food, accelerate food deterioration and cause serious problems of food safety (Choe & Min, 2006). Excess free radicals
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br Depletion of serum amino
2023-03-02
Depletion of serum amino acids Currently, the only anticancer agents that directly target amino Azacyclonol metabolism are bacterial l-asparaginases (from Escherichia coli and Erwinia chrysanthemi), which are FDA-approved for treatment of pediatric and adult ALL. A potential complication of using
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br Conclusions br Introduction During numerous
2023-03-02
Conclusions Introduction During numerous physiological processes, aldehydes are generated from a variety of endogenous and exogenous precursors including amino acids, carbohydrates, and lipids [1]. Most aldehydes are highly reactive and cytotoxic due to the strong electrophilic nature of the t
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The synthetic adipoR agonists AdipoRon and are both
2023-03-02
The synthetic adipoR agonists, AdipoRon (1) and 112254 (2), are both detectable in human plasma [18]. However, with increasing knowledge about their metabolism [19], a method for detection from human urine is conceivable and would be preferred given the easier accessibility and greater frequency of
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br Materials and methods br Discussion Few studies
2023-03-02
Materials and methods Discussion Few studies have examined peripheral PACAP levels in migraineurs, and no reports have described PACAP levels in blood samples from patients with CM. Here, we demonstrated that plasma PACAP concentrations were lower in patients with interictal migraine (in both
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Moreover our results indicate that
2023-03-02
Moreover, our results indicate that ADP is by far a better phosphate donor than AMP (Table 2). Yet, the bindings of AMP and ATP are mutually exclusive, whereas the bindings of ADP and ATP are additive (Fig. 7). The multiplicity of the phosphate donors in the TgAK reaction (Tables 1 & 2), suggests th
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br Roles for GMF in Endocytic
2023-03-02
Roles for GMF in Endocytic Traffic In addition to its roles in cell migration, GMF regulates actin-dependent endocytosis in yeast and mammals 13, 14, 50, and promotes the turnover of focal adhesions in immune SQ 29,548 42, 51. Vinculin, a central component of focal adhesions that anchors cells t
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To date the modes of actions of pharmaceuticals
2023-03-02
To date, the modes of actions of pharmaceuticals in humans and mammals are well-known (Fent et al., 2006), whereas knowledge of aquatic organisms, particularly invertebrates, is limited. This is problematic as these contaminants/pollutants have potentially harmful effects on wildlife organisms that
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