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With regard to the first
2023-09-01
With regard to the first question, subcellular fractionation studies revealed that BDK and PPM1K are clearly detectable in both the mitochondrial and cytosolic subcellular fractions, thus making it possible for these enzymes to interact with both the BCKDH and ACL substrates. The preferential presen
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br Introduction Lipoxygenases LOXs are a heterogeneous famil
2023-09-01
Introduction Lipoxygenases (LOXs) are a heterogeneous family of enzymes that catalyze the peroxidation of polyunsaturated fatty acids (PUFAs). By oxidizing free PUFAs, they were shown to contribute to the generation of various bioactive lipid mediators. However, LOX-mediated oxidation of PUFAs es
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Previous studies have demonstrated that synaptic AMPARs can
2023-09-01
Previous studies have demonstrated that synaptic AMPARs can differ greatly in their mobility; some rapidly and constitutively integrin inhibitors in and out of the synaptic membrane, while others remain somewhat stable in the synaptic membrane (Luscher et al., 1999, Luthi et al., 1999). We find tha
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We found that decreased Ng levels
2023-09-01
We found that decreased Ng levels lead to a lower threshold for LTD induction at L4–L2/3 synapses. Previous studies in hippocampal slice culture have shown that LTD at individual synapses induces spine elimination at both the targeted synapse and selective neighboring synapses when spines are monito
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We also measured macrophage infiltration and CLS presence in
2023-09-01
We also measured macrophage infiltration and CLS presence in peri-gonadal AT from db/db mice and controls. CLS are morphological features within AT that are accurate indicators of adipocyte death and macrophage infiltration [56]. An earlier study showed that CLS macrophages account for >90% of the t
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Benzamil Modulating the ability of tumor
2023-09-01
Modulating the ability of tumor Benzamil to detoxify ROS is a key mechanism by which cysteine metabolism affects tumor cell survival. One study observed hypermethylation of cysteine dioxygenase (CDO1) in 60% of tested breast cancer samples, leading to increased ROS detoxification and tumor cell surv
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br Hypothesis The hypothesis is that AhR
2023-09-01
Hypothesis The hypothesis is that AhR in skin diseases could be an objective of study for future dermatological therapies. Both stimulation and inhibition of the receptor might have significant influences on neoplastic or inflammatory skin diseases. However, at present the functions of AhR are un
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A high throughput small molecule ACK biochemical inhibition
2023-09-01
A high-throughput small molecule ACK1 biochemical inhibition screen was performed in-house and led to the identification of 1μM inhibitor furanopyrimidine (). Further binding studies found inno-206 synthesis to be both ATP-competitive and reversible. Early structure-activity relationship (SAR) wo
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Brain damage diseases such as
2023-08-31
Brain damage diseases, such as cerebral ischemia, brain trauma and infection are characterized by the increase in oxygen free radicals. Therefore, deeper understanding of the character and mechanism of free radical damage in the brain is important to ultimately relieve diseases and promote recovery
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br Conclusion GroEL from RA CH was expressed and
2023-08-31
Conclusion GroEL from RA-CH-1 was expressed and purified. The recombinant RaGroEL protein exhibited ATPase activity, which cooperated with GroES in ATP hydrolysis. Furthermore, the expression pattern of groEL revealed that groEL was up-regulated during stress response. Further studies are warrant
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Several in vivo and in vitro studies have
2023-08-31
Several in vivo and in vitro studies have demonstrated changes in bioactive lipid profiles under hyperglycemic conditions and have linked these changes with increased leukocyte adhesion and vascular dysfunction during diabetes. This input has originated partly from lipidomic studies that showed elev
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br Acknowledgements br Introduction Double stranded
2023-08-31
Acknowledgements Introduction Double-stranded DNA breaks (DSBs) are among the most deleterious DNA lesions that threaten genomic integrity. DSBs are generated not only by exogenous DNA-damaging agents but also by normal cellular processes such as V(D)J recombination, meiosis, and DNA replicati
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The known crystal structures of class C GPCR VFTs
2023-08-31
The known crystal structures of class C GPCR VFTs do not include attached TM domains, therefore current conformational data may not accurately reflect the dynamics of extracellular domains in full-length receptors. Nevertheless, compelling mechanisms of signal transduction can still be postulated. S
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Thirdly and finally multiple studies have analyzed
2023-08-31
Thirdly and finally, multiple studies have analyzed the activation of neurons in the auditory telencephalic areas of songbirds in response to various auditory stimuli. Neuronal activation was identified by the increased expression of immediate early genes such as fos or ZENK (also know as zif-268, e
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To introduce in a simple
2023-08-31
To introduce in a simple way the variability in the concentration of the proteins involved in the process, and to consider possible stochastic effects due to possible finite sizes of the populations involved in the problem, the dynamics of each cell is studied using the Gillespie’s algorithm (Gilles
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