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In earlier experiments on snails a behavioral model
2024-01-09
In earlier experiments on snails, a behavioral model was employed of certain food rejection to study the mechanisms of the reconsolidation of long-term associative memory. It was found that conditioned food stimuli (reminder) presentation, combined with injections of NMDA glutamate receptor antagoni
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A role for YAP in mediating resistance to EGFR
2024-01-09
A role for YAP in mediating resistance to EGFR inhibition has also been described [28], [29]. In line with these evidences, we observed increased YAP activation in all the generated EGFR TKI–resistant cells, testified by decreased phosphorylation on the inhibitory serine 127, enhanced nuclear locali
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br Introduction Lung cancer is the
2024-01-09
Introduction Lung cancer is the leading cause of cancer death worldwide and is one of the most refractory of solid tumors along with pancreatic cancer. Since 1975 there have been notable improvements in the 5-year survival rate of patients with lung cancer [1]. This improvement in survival is tho
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There are in contrast many studies
2024-01-09
There are in contrast many studies demonstrating that sex steroids modulate Azithromycin synthesis processing of stimuli related to reproduction and this correlates with the observation that steroid receptors and aromatase are expressed in many brain nuclei that are part of the olfactory, visual and
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Rimonabant receptor The MOB and AOB are important in ungulat
2024-01-09
The MOB and AOB are important in ungulates (Keller and Levy, 2012, Sanchez-Andrade and Kendrick, 2009), which rely heavily on odorant information for social interactions (Baum and Cherry, 2015, Keller and Levy, 2012, Osada et al., 2014, Villagran and Ungerfeld, 2013). The release of GABA and glutama
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It is reported that calpain plays a
2024-01-09
It is reported that calpain-2 plays a critical role in BDNF-induced signaling and memory formation, and knockdown of calpain-2, but not calpain-1, completely suppresses BDNF-induced pathway activation and protein translation (Briz et al., 2013). BDNF prevents neuronal apoptosis or death (Ferrer et a
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br Conflicts of interest br Contributors
2024-01-09
Conflicts of interest Contributors Introduction Lipid oxidation and enzymatic activities are some of the most significant problems in the food industry. These reactions lead to changes in chemical composition which in turn reduce the quality and shelf life of food products. Most of the anti
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br Concluding remarks Enhanced membrane
2024-01-09
Concluding remarks Enhanced membrane binding upon calcium stimulation in Chlortetracycline HCl suggests a pre-requisite step that involves a conformational change in LOX. This might facilitate it to tether to the membrane and regulate enzyme activity. The calcium binding loops and the putative a
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5-Hydroxy-CTP The literature suggests that adiponectin has a
2024-01-08
The literature suggests that adiponectin has a steroidogenic effect on ovarian function. In pigs, in vitro studies have shown that adiponectin reduced basal testosterone secretion in internal theca cells; in granulosa cells, it increased secretion of estradiol and, in combination with insulin, incre
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Materials and methods br Results br Discussion The BV tag
2024-01-08
Materials and methods Results Discussion The BV-tag-based electrochemiluminescence immunoassay is an extremely sensitive assay. It has been employed for detecting analytes present in only picogram quantities (e.g., bacterial toxins [26], ap4 [19]), measuring the activity of basic carboxypept
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Through activation of the CD GOPC pathway attenuated vaccina
2024-01-08
Through activation of the CD46–GOPC pathway, attenuated/vaccinal MeVs rapidly induce a transient phase of autophagy which then diminishes with no signs of negative regulation and precedes a second autophagy phase related to viral protein synthesis [115]. In sharp contrast, virulent MeVs do not inter
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br Results br Discussion br Conclusion The
2024-01-08
Results Discussion Conclusion The flux of glucose into cytosolic short chain acyl-CoAs was maintained in pure beta Bryostatin 1 in the presence of inhibition of ATP citrate lyase with hydroxycitrate and also in a cell line with >90% ATP citrate lyase knockdown suggesting that a pathway othe
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Despite the absence of disulfide bonds in its
2024-01-08
Despite the absence of disulfide bonds in its linear structure, KT43C displays antifungal and antibacterial activity. Disulfide bonds are determinants of defensins' integrity and have been reported to increase the antimicrobial activity (Jenssen et al., 2006). However, some linear derivatives of AMP
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It has been proposed that angiotensin II Ang
2024-01-08
It has been proposed that angiotensin II (Ang II) may upregulate COX-2 expression and the subsequent vasoconstrictor prostanoids production through the activation of AT-1 receptors in vascular smooth muscle cells (Hu et al., 2002). Additionally, this peptide is also able to stimulate the generation
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Em um estudo com modelos
2024-01-05
Em 2011, um estudo com modelos de ratinhos triplamente mutados para KT 5720 sale doença de Alzheimer expôs um grupo a anestesia geral com halotano ou isoflurano cinco horas por semana durante quatro semanas (a três diferentes idades: dois, quatro e seis meses) e um grupo sem exposição aos anestésico
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